HORDB

ID: hor000812
Uniprot ID: Q5DW47
Protein name: Pro-corazonin (Potential)
Gene name: Crz
Organism: Apis mellifera (Honeybee)
Family: Corazonin family
Source: animal
Expression: In the adult brain, expressed in four neurons of the lateral protocerebrum project axons towards the retrocerebral complex.
Disease: NA
Comments: NA
Taxonomy: Apis (genus), Apini (tribe), Apinae (subfamily), Apidae (family), Apoidea (superfamily), Aculeata (infraorder), Apocrita (suborder), Hymenoptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005184 neuropeptide hormone activity; GO:0071858 corazonin receptor binding
GO BP: GO:0007218 neuropeptide signaling pathway; GO:0045823 positive regulation of heart contraction
GO CC: GO:0005576 extracellular region

Sequence: QTFTYSHGWTNGKRSTSLEELANRNAIQSDNVFANCELQKLRLLLQGNINNQLFQTPCELLNFPKRSFSENMINDHRQPAPTNNNY
Length: 86(22-107)
Propeptide: MVNSQILILFILSLTITIVMCQTFTYSHGWTNGKRSTSLEELANRNAIQSDNVFANCELQKLRLLLQGNINNQLFQTPCELLNFPKRSFSENMINDHRQPAPTNNNY
Signal peptide: MVNSQILILFILSLTITIVMC
Modification: T1 Pyrrolidone carboxylic acid;T11 Asparagine amide
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor000812_AF2.pdb

hor000812_ESM.pdb

Mass:	1147334	Formula:	C432H670N130O136S3
Absent amino acids:		Common amino acids:	N
pI:	8.23	Basic residues:	10
Polar residues:	33	Hydrophobic residues:	24
Hydrophobicity:	-87.09	Boman Index:	-21970
Half-Life:	0.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	66.98
Instability Index:	5426.16	Extinction Coefficient cystines:	8605
Absorbance 280nm:	101.24